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KMID : 0363320060270030589
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Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 3 p.589 ~ p.602
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Effect of Hwangryunagyotang Water Extract on Endothelial Cells by Free Cholesterol
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Lee So-Yeon
Yoon Hyun-Duk
Shin Oh-Chul
Shin Yoo-Jung
Park Chi-Sang
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Abstract
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Hwangryunagyotang is supposed to have significant effects on some sorts of cardiovascular diseases like atherosclerosis. For this study. ACAT inhibitor was put in LDLR -/- mice to derive free cholesterol from it. This was to examine the effectiveness of Hwangryunnagyotang on its protecting and recovering function with endothelial cells damaged by free cholesterol through experimental. The results reported below. Hwangryunagyotang suppressed the crystallization of reactive oxygen species in macrophages and the numbers of free cholesterol crystal plate structured and reduced fragmentation of nucleus in ECV 304 cell strain by ACAT inhibitor significantly. Hwangryunagyotang also suppressed the necrosis of tissue in LDLR -/- mice’ (treated with ACAT inhibitor) inflammatory portion which is adjacent to aortic root, proximal aorta and carotid artery by immunohistochemistry and fluorescence microscopy. On the whole, Hwangryunagyotang suppressed the necrosis of endothelial cells and especially it’s effcet for the necrosis of para-myocardial tissues by free cholesterol. With this result, I suggest Hwangryunagyotang might have protective and recovery effects on atherosclerosis, so we need to carry on this study henceforth clinically and experimentally as well.
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KEYWORD
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Hwangryunagyotang, atherosclerosis, free cholesterol
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